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[Tauopathies : From molecule to therapy].

G G Kovacs¹, G Respondek^2,3, T van Eimeren^4,5,6

¹Klinisches Institut für Neurologie, Medizinische Universität Wien, Wien, Österreich.

|August 19, 2018

Summary

This summary is machine-generated.

Recent advances reveal tau protein’s variability in neurodegenerative tauopathies, impacting diagnosis and treatment. Understanding tau pathology is crucial for developing new therapies and clinical trials.

Keywords:

Biomarker Causal therapy Corticobasal degeneration Microtubule-associated tau protein Progressive supranuclear palsy

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Area of Science:

Neuroscience
Genetics
Pathology

Background:

Tauopathies are neurodegenerative diseases defined by the microtubule-associated tau protein.
Tau protein pathology is central to a spectrum of neurological disorders.

Purpose of the Study:

To provide a state-of-the-art review of recent scientific advances in tauopathies.
To highlight progress in understanding tau protein's role in disease.

Main Methods:

Systematic literature review.
Analysis of research published over the past 10 years.

Main Results:

Tau protein is highly variable, defining molecularly distinct diseases with diverse clinical presentations, from dementia to movement disorders.
Genetic variations influence tauopathy risk and disease onset.
Tau pathology damages neurons and spreads through the brain, suggesting potential as biomarkers.
Tau protein alterations offer therapeutic targets for disease modification.

Conclusions:

The field of tauopathies is rapidly evolving.
Interdisciplinary collaboration is essential for continued progress in understanding and treating tauopathies.