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Related Concept Videos

Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Peripheral Artery Disease IV: Nursing Management01:26

Peripheral Artery Disease IV: Nursing Management

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 The nursing management of a patient with peripheral artery disease (PAD) begins with a thorough assessment of the patient’s health history and clinical manifestations.AssessmentHealth History: Evaluate the patient’s history of hypertension, hyperlipidemia, family history of cardiovascular issues, and lifestyle factors such as dietary patterns, smoking, and physical activity.Physical Examination:Assess the affected extremity for decreased or absent peripheral pulses,...
389
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Assessment of Diffusion and Perfusion01:17

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Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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A correlative study between diffusion and perfusion MR imaging parameters on peripheral arterial disease data.

Georgios S Ioannidis1, Kostas Marias2, Nikolaos Galanakis3

  • 1Foundation for Research and Technology - Hellas (FORTH), Institute of Computer Science (ICS), Computational Bio-Medicine Laboratory (CBML), Heraklion, Greece; Medical School, University of Crete, Heraklion, Greece.

Magnetic Resonance Imaging
|August 20, 2018
PubMed
Summary

Smoothing diffusion and perfusion MRI data reveals significant correlations in patients with peripheral arterial disease. This finding suggests that diffusion MRI can provide valuable perfusion information, aiding in the assessment of lower limb ischemia.

Keywords:
Diffusion weighted imagingDynamic contrast enhanced MR imagingIntravoxel incoherent motionMutual information (MI)Pearson's correlation coefficientPeripheral arterial disease

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Area of Science:

  • Medical Imaging
  • Radiology
  • Biophysics

Background:

  • Peripheral arterial disease (PAD) affects lower limb circulation, necessitating advanced imaging techniques for accurate assessment.
  • Diffusion MRI (dMRI) and Dynamic Contrast-Enhanced MRI (DCE-MRI) offer complementary physiological information but require robust correlation methods.

Purpose of the Study:

  • To correlate quantitative and semi-quantitative diffusion and perfusion MR parameters in patients with peripheral arterial disease.
  • To identify the most suitable perfusion model for describing DCE-MRI data in ischemic lower limb regions.

Main Methods:

  • Employed linear and nonlinear least squares algorithms for parameter quantification using established models (Intra-voxel Incoherent Motion for dMRI; Patlak's, Extended Toft's, GCTT for DCE-MRI).
  • Implemented all numerical calculations in Python 3.5.
  • Applied a Gaussian filter to parametric maps to mitigate noise and enable data comparability.

Main Results:

  • Initial voxel-by-voxel analysis showed no significant Pearson's correlation between diffusion and perfusion parameters.
  • After applying a Gaussian filter to the parametric maps, a strong positive correlation (>0.5) was observed between diffusion and perfusion parameters.

Conclusions:

  • Quantitative and semi-quantitative parameters from both dMRI and DCE-MRI can be extracted using various physiological-pharmacokinetic models.
  • Smoothing of parametric maps is crucial for revealing significant correlations between diffusion and perfusion MRI parameters in PAD patients.
  • Diffusion MRI holds potential for extracting perfusion-related information in the lower limbs of patients with peripheral arterial disease.