Related Experiment Video

Updated: Feb 6, 2026

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies
11:12

Immunometabolic Circuits in Infection for Advancing Host Directed Therapies

Published on: September 13, 2024

947

Nano-engineered delivery systems for cancer imaging and therapy: Recent advances, future direction and patent

Ghazal Nabil1, Ketki Bhise2, Samaresh Sau2

  • 1Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI, USA; Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Drug Discovery Today
|August 20, 2018
PubMed

Insights

Nanotheranostics, combining polymer and metal nanoparticles, offers dual early diagnosis and therapy for cancer. This review explores their limitations, future applications like cancer vaccination, and clinical trials, highlighting microenvironment impacts.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Cancer remains a leading global cause of mortality.
  • Conventional treatments face limitations in efficacy and specificity.
  • Nanotheranostics presents a personalized medicine approach for cancer management.

Purpose of the Study:

  • To review theranostic polymer and metal nanoparticles for cancer therapy and imaging.
  • To discuss limitations and future applications of nanotheranostics.
  • To explore the influence of the biological microenvironment on nanoparticle behavior.

Main Methods:

  • Literature review of nanotheranostic applications in cancer.
  • Analysis of polymer and metal nanoparticles for therapeutic and diagnostic roles.
  • Examination of patent applications and clinical trials.

Main Results:

  • Nanotheranostics demonstrate potential for early cancer detection and treatment.
  • Future applications include cancer vaccination, gene delivery, and immune modulation.
  • Biological microenvironment significantly affects nanoparticle biodistribution and accumulation.

Conclusions:

  • Nanotheranostic nanoparticles are promising tools for advanced cancer care.
  • Further research is needed to overcome limitations and optimize clinical translation.
  • Understanding microenvironment interactions is crucial for effective nanotherapeutic design.

More Related Videos

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.4K
Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy07:12

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy

Published on: September 27, 2021

2.8K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Evaluating Limits by Direct Substitution01:29

Evaluating Limits by Direct Substitution

In the analysis of functions that represent continuous physical phenomena, it is often necessary to determine the output value as the input approaches a specific point. When a combination of algebraic terms defines the function and exhibits no discontinuities or abrupt changes near the point of interest, the limit of the function can be evaluated directly. This process, known as direct substitution, involves replacing the variable in the expression with the value it approaches.Direct...
179
What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
80.3K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K