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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Electrochemotherapy of Tumours
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Malignant proliferating trichilemmal tumour.

Prateush Singh1, Ayesha Usman2, Luisa Motta3

  • 1Department of Plastic Surgery, Royal Free Hospital, London, UK.

BMJ Case Reports
|August 20, 2018
PubMed
Summary

Proliferating trichilemmal tumours are rare, locally aggressive skin neoplasms originating from hair follicles. Early diagnosis and management are crucial to prevent malignant transformation and metastasis.

Keywords:
plastic and reconstructive surgeryskin

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Proliferating trichilemmal tumours (PTTs) are neoplasms originating from the outer root sheath of hair follicles.
  • These tumours are typically benign but exhibit locally aggressive behaviour.

Observation:

  • PTTs can rarely undergo malignant transformation.
  • Malignant PTTs pose a risk of recurrence and distant metastasis.

Findings:

  • A high index of suspicion is necessary for diagnosing PTTs due to their rarity.
  • Prompt and appropriate management is essential for PTTs.

Implications:

  • Early detection and intervention are critical for improving patient outcomes.
  • Understanding the malignant potential of PTTs informs treatment strategies.