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POMME: The New Cohort to Evaluate Long-Term Effects After Prenatal Medicine Exposure

Justine Benevent1,2,3, Caroline Hurault-Delarue4, Mélanie Araujo4

  • 1Laboratoire de Pharmacologie Médicale et Clinique, Faculté de Médecine de Toulouse, Toulouse, France. justine.benevent@univ-tlse3.fr.

Drug Safety
|August 20, 2018
PubMed

Insights

The PrescriptiOn Médicaments Mères Enfants (POMME) cohort tracks children

Area of Science:

  • Pediatric pharmacology and developmental toxicology.
  • Epidemiology of medication use in pregnancy and childhood.
  • Public health and healthcare utilization research.

Background:

  • The PrescriptiOn Médicaments Mères Enfants (POMME) cohort was established to evaluate long-term health outcomes following prenatal medication exposure.
  • It links anonymous medical data with medication and healthcare reimbursement information from birth through childhood.

Purpose of the Study:

  • To describe the structure and content of the POMME cohort.
  • To outline potential research studies using this novel data source.
  • To facilitate the assessment of risks associated with prenatal medicine exposure.

Main Methods:

  • Data integration from the French Health Insurance Database (medications, reimbursements) and the Mother and Child Protection Centre Database (health certificates).
  • Inclusion of children born in Haute-Garonne, France, over a one-year period, with data collection every five years.
  • Cohort initiation on July 1, 2010, with follow-up data available.

Main Results:

  • The POMME cohort includes 8372 children, now aged 7 years.
  • Prenatal medication exposure averaged 9.8 medications; post-natal exposure was highest in 0-2 year olds.
  • Commonly exposed drug classes include paracetamol, anti-infectives, and respiratory agents; 10.8% showed psychomotor development disorders.

Conclusions:

  • The POMME cohort serves as a valuable resource for observational studies on pediatric drug exposure and healthcare utilization.
  • It enables the assessment of long-term health consequences stemming from prenatal medication exposure.
  • This innovative cohort supports research into the impact of medications during pregnancy on child development.
Abstract

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