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Related Experiment Videos

Combined pituitary function-test with four hypothalamic releasing hormones.

J Schopohl, M Losa, A König

    Klinische Wochenschrift
    |April 1, 1986
    PubMed
    Summary
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    Combined administration of four pituitary releasing hormones (RH) effectively assesses anterior pituitary function. Terguride, a dopamine agonist, blunts the prolactin and TSH response to RH stimulation.

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Pharmacology

    Background:

    • Anterior pituitary function is regulated by releasing hormones (RH) and influenced by dopamine agonists.
    • Assessing pituitary reserve is crucial, especially in patients on dopamine agonist therapy.

    Purpose of the Study:

    • To investigate the effect of combined releasing hormone (RH) administration on anterior pituitary function.
    • To evaluate the impact of terguride, a dopamine agonist, on the pituitary response to RH stimulation.

    Main Methods:

    • Ten healthy subjects received a combination of thyrotropin-releasing hormone (TRH), gonadotropin-releasing hormone (GnRH), growth hormone-releasing factor (GRF1-44), and corticotropin-releasing factor (CRF).
    • The same protocol was repeated after pretreatment with terguride (0.25 mg).

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  • Subgroups were tested with individual RHs or combinations.

    • Main Results:

    • Combined RH administration promptly increased all measured pituitary hormones.
    • Terguride pretreatment significantly reduced the prolactin (PRL) and thyrotropin (TSH) response to RH stimulation (p < 0.01 and p < 0.05, respectively).
    • Combined RH administration resulted in higher PRL levels compared to TRH and GnRH alone.

    Conclusions:

    • Combined RH administration is a valuable tool for assessing anterior pituitary function.
    • Dopamine agonists like terguride can modulate pituitary hormone release in response to RH stimulation.
    • This testing approach remains useful even in patients undergoing dopamine agonist therapy.