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Updated: Feb 6, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
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A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

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Cross-Generational Contributors to Preterm Birth in California: Singletons Based on Race/Ethnicity

Lissa N Francois1, Juan Yang2, Rebecca J Baer3,4

  • 1Maternal Fetal Medicine Center, Valley Children's Healthcare, Madera, California.

American Journal of Perinatology
|August 20, 2018
PubMed

Insights

Maternal history of preterm birth (PTB) increases the risk of PTB across all racial and ethnic groups. Hypertension was the only consistent risk factor identified across generations for PTB.

Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Sociodemographic Factors in Obstetrics

Background:

  • Cross-generational patterns of preterm birth (PTB) are inconsistently reported.
  • Existing studies often lack diversity, focusing primarily on white populations.
  • Understanding PTB risk across different racial/ethnic groups is crucial for targeted interventions.

Purpose of the Study:

  • To examine the cross-generational risk of preterm birth (PTB) across diverse racial and ethnic groups.
  • To identify sociodemographic, socioeconomic, and clinical factors associated with intergenerational PTB.
  • To determine if PTB risk factors vary by maternal race/ethnicity.

Main Methods:

  • Retrospective study of 388,474 grandmother-mother-infant triads.
  • Data sourced from California singleton live birth registry (2005-2011).
  • Logistic regression analysis (ORs, CIs) stratified by maternal race/ethnicity.

Main Results:

  • Women born preterm had a significantly higher risk of delivering preterm infants (<32 weeks: OR 2.09; 32-36 weeks: OR 1.51).
  • This increased risk was observed across all racial/ethnic groups (White, Black, Hispanic, Asian).
  • Hypertension was the sole consistent risk factor associated with increased PTB across generations.

Conclusions:

  • A consistent cross-generational risk of preterm birth (PTB) exists across racial and ethnic groups.
  • Hypertension emerges as a critical, consistent risk factor in intergenerational PTB.
  • Findings underscore the need for race/ethnicity-inclusive research and interventions for PTB prevention.
Abstract

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