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Does Blood Flow Change according to Mood? Blood Rheology in Bipolar Disorder

Tevfik Kalelioglu1, Murat Kocabiyik2, Burcu Kok1

  • 1Department of Psychiatry, Bakırköy Mental Health Research and Teaching Hospital, Istanbul, Turkey.

Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology
|August 21, 2018
PubMed

Insights

Whole blood viscosity (WBV) was lower in manic bipolar disorder patients compared to euthymic patients and healthy controls. This suggests a potentially favorable effect on cardiovascular risk during manic episodes.

Area of Science:

  • Cardiovascular Health
  • Psychiatric Disorders
  • Rheology

Background:

  • Bipolar disorder (BD) is linked to higher cardiovascular disease (CVD) rates.
  • Blood viscosity is increasingly recognized as a factor in CVD development.
  • Investigating blood viscosity in different BD states is crucial for understanding CVD risk.

Purpose of the Study:

  • To examine whole blood viscosity (WBV) in individuals with bipolar disorder across various mood states.
  • To correlate WBV with cardiovascular risk factors in bipolar disorder patients.

Main Methods:

  • 121 bipolar patients (manic, depressed, euthymic) and 41 controls were analyzed.
  • Whole blood viscosity (WBV) was calculated using Simone's formula at low and high shear rates (LSR and HSR).
  • WBV was assessed in relation to mood state and lipid profiles.

Main Results:

  • Manic patients exhibited significantly lower WBV at both HSR and LSR compared to euthymic patients and controls (p < 0.01).
  • WBV showed a positive correlation with lipid profiles, excluding high-density lipoprotein (HDL).
  • A negative correlation was observed between WBV and the number of previous manic episodes.

Conclusions:

  • Manic episodes are associated with reduced blood viscosity, potentially indicating a favorable impact on cardiovascular risk.
  • Blood viscosity in bipolar disorder is linked to lipid profiles and the history of manic episodes.
  • Further research is warranted to elucidate the mechanisms underlying these findings and their clinical implications.
Abstract

Keywords:
Bipolar disorderBlood viscosityCardiovascular risk.

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