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Monitoring antiangiogenesis of bevacizumab in zebrafish

Jing Zhang1,2, Beili Gao1, Wenchao Zhang1

  • 1Department of Respiratory and Critical Care Medicine, Ruijin Hospital, Institute of Respiratory Diseases, School of Medicine, Shanghai Jiaotong University, Shanghai, People's Republic of China, xiangyiht@163.com.

Drug Design, Development and Therapy
|August 21, 2018
PubMed

Insights

Bevacizumab effectively suppresses blood vessel formation in zebrafish models, offering a new visual method to study anti-angiogenesis. This research highlights its potential for treating conditions involving abnormal blood vessel growth.

Area of Science:

  • Developmental Biology
  • Pharmacology
  • Cancer Research

Background:

  • Bevacizumab, a humanized anti-VEGF antibody, has clinical applications since 2004, primarily in solid tumors combined with chemotherapy.
  • Existing research on bevacizumab's anti-angiogenesis mechanisms relies heavily on mouse models, lacking intuitive visual observation methods.
  • There is a need for accessible models to visualize and understand the anti-angiogenesis activity of bevacizumab.

Purpose of the Study:

  • To utilize a zebrafish model for investigating the anti-angiogenesis effects of bevacizumab.
  • To establish a visual and intuitive model for observing bevacizumab's mechanism of action in suppressing blood vessel formation.
  • To explore the therapeutic potential of bevacizumab in inhibiting angiogenesis.

Main Methods:

  • Employing a zebrafish model to assess bevacizumab's impact on vasculature development.
  • Observing and quantifying the inhibition of subintestinal vein formation in zebrafish embryos.
  • Analyzing specific vasculature defects induced by bevacizumab in different embryonic tissues.
  • Evaluating bevacizumab's effect on retinal angiogenesis in the zebrafish model.

Main Results:

  • Bevacizumab significantly inhibited the formation of zebrafish subintestinal veins, a process analogous to tumor angiogenesis.
  • The drug induced specific defects in subintestinal vein vasculature but did not affect trunk vasculature.
  • Bevacizumab demonstrated efficacy in suppressing zebrafish retinal angiogenesis, indicating therapeutic potential.
  • The zebrafish model provided a clear, visual representation of bevacizumab's anti-angiogenic activity.

Conclusions:

  • The zebrafish model serves as an effective and intuitive platform for studying bevacizumab's anti-angiogenesis effects.
  • Bevacizumab's ability to inhibit both subintestinal vein and retinal angiogenesis in zebrafish suggests broad therapeutic applicability.
  • This study provides valuable insights into the mechanisms of bevacizumab and supports its continued use in anti-cancer therapies.
Keywords:
VEGFanti-angiogenesisbevacizumabsubintestinal veinzebrafish

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