Current treatment options for acanthosis nigricans.

Area of Science:

• Dermatology
• Endocrinology
• Internal Medicine

Background:

• Acanthosis nigricans (AN) is a common skin condition often indicating underlying systemic diseases.
• It is frequently associated with insulin resistance, diabetes mellitus, obesity, malignancy, and endocrine disorders.
• The characteristic skin changes include velvety, hyperpigmented, and hyperkeratotic plaques.

Purpose of the Study:

• To review and evaluate the existing treatment options for Acanthosis nigricans.
• To explore therapeutic strategies addressing both the primary underlying conditions and the cosmetic aspects of AN lesions.
• To consolidate current knowledge on AN management due to limited extensive research.

Main Methods:

• Literature review of existing clinical trials and case reports on Acanthosis nigricans treatment.
• Evaluation of therapeutic interventions targeting the resolution of underlying systemic diseases.
• Assessment of treatment modalities aimed at improving the cosmetic appearance of AN skin lesions.

Main Results:

• Treatment of AN primarily involves addressing the root cause, such as managing diabetes or obesity.
• While not extensively studied, various treatment options exist, supported by smaller trials and case reports.
• Cosmetic improvement of AN lesions is a significant factor for patient quality of life.

Conclusions:

• Effective management of Acanthosis nigricans requires addressing associated systemic diseases.
• Current treatment options, though not exhaustively studied, offer potential for both medical and cosmetic improvement.
• Further research is warranted to establish evidence-based guidelines for AN treatment.