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Association of renal systolic time intervals with brachial-ankle pulse wave velocity

Wen-Hsien Lee1,2,3,4, Po-Chao Hsu2,4, Chun-Yuan Chu2,4

  • 1Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

International Journal of Medical Sciences
|August 21, 2018
PubMed

Insights

Renal systolic time intervals, specifically renal pre-ejection period (PEP) and renal PEP/ET ratio, are independently linked to arterial stiffness, measured by brachial-ankle pulse wave velocity (baPWV). This finding suggests renal echo measurements may correlate with vascular health.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Diagnostic Imaging

Background:

  • Renal systolic time intervals (STIs) like renal pre-ejection period (PEP) and renal ejection time (ET) are indicators of cardiac function.
  • Arterial stiffness, assessed by brachial-ankle pulse wave velocity (baPWV), is a marker of cardiovascular risk.
  • The relationship between renal STIs and arterial stiffness has not been previously explored.

Purpose of the Study:

  • To investigate the association between renal STIs (renal PEP, renal ET, renal PEP/ET) and arterial stiffness (baPWV).

Main Methods:

  • A cross-sectional study involving 230 patients.
  • Renal hemodynamics measured using Doppler ultrasonography.
  • Arterial stiffness assessed via brachial-ankle pulse wave velocity (baPWV) using an oscillometric device.

Main Results:

  • Higher baPWV values correlated with increased renal resistive index (RI) and decreased renal PEP and renal PEP/ET.
  • Multivariable analysis revealed renal PEP and renal PEP/ET as independent determinants of baPWV.
  • Renal RI was not found to be an independent predictor of baPWV in the multivariable model.

Conclusions:

  • Renal pre-ejection period (PEP) and the renal PEP/ET ratio are independently associated with arterial stiffness (baPWV).
  • Renal STIs derived from renal ultrasound may serve as a valuable non-invasive marker for assessing arterial stiffness.

Keywords:
Systolic time intervalsarterial stiffnessblood pressurebrachial-ankle pulse wave velocityrenal Doppler

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