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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Oncogenic and tumor suppressive roles of special AT-rich sequence-binding protein

Qiao Yi Chen1, Max Costa1

  • 1Department of Environmental Medicine, New York University School of Medicine, NY, USA.

Journal of Carcinogenesis
|August 21, 2018
PubMed

Insights

Special AT-rich sequence-binding protein 2 (SATB2) has a dual role in cancer, acting as both a tumor suppressor and promoter. Further research is needed to clarify its function in different tumor types.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Special AT-rich sequence-binding protein 2 (SATB2) is implicated in cancer development.
  • Conflicting evidence exists regarding SATB2's role as a tumor suppressor or promoter.
  • Variations in study models (tumor tissues, cell lines) contribute to mixed findings.

Purpose of the Study:

  • To comprehensively review current research on SATB2's function in various cancer types.
  • To elucidate the contradictory roles of SATB2 in cancer progression.
  • To provide insights for future research directions.

Main Methods:

  • Systematic literature search on PubMed using keywords "SATB2" and "special AT-rich sequence-binding protein 2."
  • Article selection based on title relevance.
  • Cross-referencing of cited articles to identify additional relevant studies.

Main Results:

  • SATB2 exhibits context-dependent roles, functioning as both a tumor suppressor and promoter.
  • Its activity is influenced by multiple regulatory factors.
  • SATB2 targets diverse downstream genes across different cancer cell lines and tissues.

Conclusions:

  • SATB2's role in cancer is complex and multifaceted.
  • Further investigation into its specific functions in distinct tumor types is warranted.
  • Understanding SATB2's dual role is crucial for cancer research and therapeutic strategies.
Keywords:
Carcinogenesisoncogenespecial AT-rich sequence-binding proteintumor suppressor

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