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Related Experiment Videos

'Malignant' hypertension from hyperaldosteronism: a case report.

Krishna Mohan Baradhi1, Thao Tran1, Penchala Swamy Mittadodla2

  • 1University of Oklahoma, Department of Internal Medicine/Nephrology, Tulsa Schusterman Center, Tulsa, Oklahoma, USA, 74135.

The Pan African Medical Journal
|August 21, 2018
PubMed
Summary
This summary is machine-generated.

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Recurrent hyperaldosteronism from metastatic adrenocortical carcinoma (ACC) is rare. Early detection through blood pressure monitoring is crucial for patients with a history of ACC, even after surgery.

Area of Science:

  • Endocrinology
  • Oncology
  • Nephrology

Background:

  • Adrenocortical carcinoma (ACC) is a rare malignancy with low incidence.
  • Functional ACC commonly presents as Cushing syndrome.
  • Recurrent hyperaldosteronism from metastatic ACC is exceptionally uncommon.

Observation:

  • A 67-year-old female with an 8-cm right ACC presented with hypertensive urgency and hypokalemia due to hyperaldosteronism.
  • Initial surgery (nephrectomy with adrenalectomy) normalized blood pressure.
  • Recurrence manifested as resistant hypertension from hyperaldosteronism, with pulmonary metastases confirmed by biopsy.

Findings:

  • Metastatic functional ACC can recur years after curative surgery.
  • Recurrent hyperaldosteronism is a key indicator of metastatic ACC.
Keywords:
Secondary hypertensionadrenocortical carcinomahyperaldosteronismhypokalemia

Related Experiment Videos

  • Pulmonary metastases were identified in this patient.

    • Implications:

    • Metastatic functional ACC recurrence should be suspected in patients with secondary hypertension and a history of ACC.
    • Regular blood pressure monitoring is vital for early detection of ACC recurrence post-surgery.
    • Close surveillance can improve outcomes for patients with adrenocortical carcinoma.