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Updated: Feb 6, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
Immunoglobulin A Myeloma in a Newly Diagnosed Sickle Cell Disease Patient
John Ayodele Olaniyi1, Khadijah Bolanle Shonde-Adebola2
1Department of Haematology, College of Medicine, University of Ibadan/University College Hospital, Ibadan, Nigeria.
Abstract:
Several neoplasms including hematological malignancies occurring in very few patients with sickle cell syndromes have been reported in literature, particularly as survival among these patients and diagnostic accuracy have continued to improve. Multiple myeloma (MM) has rarely been reported in patients with hemoglobin (Hb) S + C. We report a 65-year-old retired banker who was recently diagnosed with HbS + C. This patient developed MM with markedly elevated erythrocyte sedimentation rate, mild anemia, 80% bone marrow plasmacytosis, and elevated serum immunoglobulin A level, while plain X-ray of the lumbosacral spine showed multilevel vertebral collapse.
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