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Published on: September 27, 2024
Facial angiofibromas treated by rapamycin 0.05% ointment and a combined laser therapy
Francesca Negosanti1, Vera Tengattini2, Carlotta Gurioli2
1Centro Dermatologico, Bologna, Italy.
Background:
Tuberous sclerosis is an autosomal dominant genodermatosis characterized by nonmalignant hamartomas in multiple organs. Facial angiofibromas are most commonly located on the face and have the potential to cause disfigurement. Facial disfigurement negatively affects the quality of life of patients and their families, often leading to negative psychosocial outcomes. Nowadays there are no treatment guidelines for facial angiofibromas but due to the progressive nature of facial angiofibromas a safe technique offering good results is needed.
Objective And Results:
We report the case of a 40-year-old female affected by tuberous sclerosis, whose facial angiofibromas were satisfactorily treated by rapamycin 0.05% ointment, and a combined laser therapy.
Insights
Facial angiofibromas in tuberous sclerosis can cause disfigurement. A combination of topical rapamycin and laser therapy effectively treated these growths, improving patient quality of life.
Area of Science:
- Dermatology
- Genetics
- Oncology
Background:
- Tuberous sclerosis is an autosomal dominant genodermatosis causing hamartomas in multiple organs.
- Facial angiofibromas, common in tuberous sclerosis, can lead to significant disfigurement and psychosocial distress.
- Current treatment guidelines for facial angiofibromas are lacking, necessitating safe and effective therapeutic options.
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