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Hemolytic characteristics of three suctioning systems for use with a newly developed cardiopulmonary bypass system

Yuki Michinaga1,2, Tamaki Takano3, Takamitsu Terasaki3

  • 11 Department of Cardiovascular Surgery, Shinshu University School of Medicine, Matsumoto, Japan.

Perfusion
|August 21, 2018
PubMed

Insights

Wall suction demonstrated the lowest hemolysis in vitro and proved effective in clinical trials for the Dihead cardiopulmonary bypass (CPB) system. This suggests wall suction is a feasible option for coronary artery bypass grafting (CABG) surgery.

Area of Science:

  • Cardiovascular Surgery
  • Biomedical Engineering
  • Hemodynamics

Background:

  • Developing a closed-circuit cardiopulmonary bypass (CPB) system, "Dihead CPB," for coronary artery bypass grafting (CABG) and valve surgery.
  • Minimizing hemolysis is crucial for patient safety during CPB procedures.

Purpose of the Study:

  • To compare the hemolysis levels of three different suction systems (roller-pump, SmartSuction, and wall suction) during CPB.
  • To evaluate the clinical feasibility and effectiveness of the Dihead CPB system with the optimal suction method.

Main Methods:

  • In vitro studies comparing hemolysis and suction speed across roller-pump, SmartSuction, and wall suction systems.
  • A clinical study involving 15 volunteers using the Dihead CPB system with wall suction to assess hemolysis and suction adequacy.

Main Results:

  • Wall suction exhibited the lowest hemolysis rate (0.41 ± 0.11%) compared to roller suction (0.61 ± 0.10%) and SmartSuction (2.00 ± 0.33%) in vitro (p<0.001).
  • SmartSuction provided the fastest suction speed, while wall suction demonstrated efficient performance in the clinical study with no significant increase in plasma free hemoglobin.

Conclusions:

  • Wall suction is associated with significantly less hemolysis than roller or SmartSuction systems.
  • The Dihead CPB system combined with wall suction is clinically feasible for CABG surgery, offering efficient suction and acceptable hemolysis levels.
Abstract

Keywords:
cardiopulmonary bypassclosed circuitfree hemoglobinhemolysisnegative pressure

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