Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Flow02:39

Gene Flow

38.0K
Gene flow is the transfer of genes among populations, resulting from either the dispersal of gametes or from the migration of individuals.
38.0K
Gene Conversion02:08

Gene Conversion

10.7K
Other than maintaining genome stability via DNA repair, homologous recombination plays an important role in diversifying the genome. In fact, the recombination of sequences forms the molecular basis of genomic evolution. Random and non-random permutations of genomic sequences create a library of new amalgamated sequences. These newly formed genomes can determine the fitness and survival of cells. In bacteria, homologous and non-homologous types of recombination lead to the evolution of new...
10.7K
Gene Families01:57

Gene Families

10.0K
Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
10.0K
Gene Therapy00:59

Gene Therapy

27.6K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
What is Gene Expression?01:42

What is Gene Expression?

196.9K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.9K
Organization of Genes02:07

Organization of Genes

73.6K
Overview
73.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficient evidence-based genome annotation with EviAnn.

Nature methods·2026
Same author

Testing the reliability of AI-generated protein structures.

bioRxiv : the preprint server for biology·2026
Same author

Comparison of unbiased metagenomic next generation sequencing to targeted multiplex diagnostic assays for the detection of respiratory viruses.

PloS one·2026
Same author

Evidence of off-target probe binding affecting 10x Genomics Xenium gene panels compromise accuracy of spatial transcriptomic profiling.

eLife·2026
Same author

A reference genome sequence for the exceptionally long-lived Great Basin bristlecone pine, Pinus longaeva.

G3 (Bethesda, Md.)·2026
Same author

Annotating genomes at increased scale and resolution.

Nature reviews. Genetics·2026

Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Advancing Gene Editing in Bamboo Leaves for Sustainable Plastic Alternatives
06:57

Author Spotlight: Advancing Gene Editing in Bamboo Leaves for Sustainable Plastic Alternatives

Published on: August 18, 2023

2.3K

Open questions: How many genes do we have?

Steven L Salzberg1

  • 1Departments of Biomedical Engineering, Computer Science, and Biostatistics, Center for Computational Biology, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Welch Medical Library, Rm. 107, 1900 E. Monument St, Baltimore, MD, 21205, USA. salzberg@jhu.edu.

BMC Biology
|August 21, 2018
PubMed
Summary

Despite the Human Genome Project, many human genes remain undiscovered. Ongoing research reveals the complexity of human gene identification is greater than initially anticipated.

More Related Videos

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
10:34

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

Published on: April 14, 2010

16.0K
Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
12:55

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Published on: January 7, 2010

24.8K

Related Experiment Videos

Last Updated: Feb 6, 2026

Author Spotlight: Advancing Gene Editing in Bamboo Leaves for Sustainable Plastic Alternatives
06:57

Author Spotlight: Advancing Gene Editing in Bamboo Leaves for Sustainable Plastic Alternatives

Published on: August 18, 2023

2.3K
Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
10:34

Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells

Published on: April 14, 2010

16.0K
Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
12:55

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Published on: January 7, 2010

24.8K

Area of Science:

  • Genomics
  • Human Genetics
  • Molecular Biology

Background:

  • The Human Genome Project aimed to sequence the entire human genome.
  • Significant progress has been made, but gene identification is incomplete.

Purpose of the Study:

  • To investigate the reasons behind the incomplete identification of human genes.
  • To explore the complexities beyond initial Human Genome Project expectations.

Main Methods:

  • Comparative genomics analysis
  • Bioinformatic approaches
  • Functional gene studies

Main Results:

  • A substantial number of protein-coding genes are still uncharacterized.
  • Novel gene families and regulatory elements have been identified.
  • The complexity of gene regulation and alternative splicing contributes to the challenge.

Conclusions:

  • Gene discovery is an ongoing process, extending beyond initial genome sequencing.
  • The human genome's complexity necessitates advanced research methods for full characterization.