Related Experiment Video
Updated: Feb 6, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
Published on: January 12, 2018
[Clinical characteristics and risk factors for feeding intolerance in preterm infants]
Xi Huang1, Qiong Chen1, Wentao Peng2
1Department of Neonatology; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China.
Insights
Feeding intolerance (FI) affects over half of preterm infants, with higher incidence in females and extremely low birth weight infants. Key risk factors include low birth weight, caffeine citrate use, and formula feeding.
Area of Science:
- Neonatology
- Pediatric Gastroenterology
- Clinical Nutrition
Background:
- Feeding intolerance (FI) is a common complication in preterm infants, impacting growth and increasing healthcare costs.
- Early identification and management of FI are crucial for improving outcomes in this vulnerable population.
Purpose of the Study:
- To investigate the clinical characteristics and risk factors associated with feeding intolerance in preterm infants.
- To provide evidence for the early identification, effective prevention, and treatment of FI in preterm neonates.
Main Methods:
- A cohort of 116 preterm infants was observed in a Neonatology department.
- Clinical data, including feeding intolerance symptoms and risk factors, were collected using a designed observation table.
- Logistic multivariate regression analysis was employed to identify significant risk factors.
Main Results:
- The incidence of feeding intolerance was 53.45%, with higher rates in females and extremely low birth weight infants.
- Abdominal distension was the most common clinical manifestation, occurring primarily within 48-72 hours of feeding.
- Significant risk factors identified were birth weight <1000g, caffeine citrate administration, and formula feeding.
Conclusions:
- Feeding intolerance is highly prevalent in preterm infants.
- Low birth weight (<1000g), caffeine citrate, and formula feeding are identified as primary risk factors for FI.
- These findings underscore the need for targeted interventions to mitigate FI in high-risk preterm infants.
Objective:
To investigate the clinical characteristics and risk factors for feeding intolerance (FI) in preterm infants and to provide evidence for early identification, effective prevention and treatment of FI. Methods: A total of 116 preterm infants were recruited in the Department of Neonatology, West China Second Hospital, Sichuan University, from July 2016 to December 2016. Self-designed "the clinical observation table for feeding intolerance of preterm infant" was used to find out the main risk factors of FI in preterm infants. Results: 1) There were 62 cases of FI. The incidence of FI in preterm infants was 53.45% (62/116). It was 44.93% (31/69) and 65.96% (31/47) for males and females, respectively, with significant difference between them (P<0.05). The incidence of FI in very low birth weight infants was 48.57% (34/70), and in the extremely low birth weight infant was 88.89% (8/9). FI in preterm infants mainly occurred in the period of being fed within 48-72 h. The symptoms included abdominal distension, gastric retention, vomiting and stomach brown color for clinical manifestations. Among them, abdominal distension was the main clinical manifestation. 2) The logistic multivariate regression analysis showed that birth weight <1 000 g (P<0.05), the use of caffeine citrate (P<0.05) and the formula feeding (P<0.05) were the main risk factors for FI. Conclusion: The incidence of FI is very high in preterm infants. Birth weight <1 000 g, the use of caffeine citrate, and formula feeding are main risk factors for FI.
More Related Videos
08:58Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs
Published on: October 31, 2025
11:50Clinical Practice Protocol of Creative Music Therapy for Preterm Infants and Their Parents in the Neonatal Intensive Care Unit
Published on: January 7, 2020
Related Concept Videos
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Characteristics of Life
Relative Risk
Characteristics of Fluids
Characteristics of Fluids
Fluids, which include both liquids and gases, are substances that deform continuously under shearing stress. For example, water and oil are liquids with molecules that can...
Characteristics of BJT
For input characteristics, the base-emitter voltage is varied, maintaining a constant collector-emitter voltage. This setup reveals a Shockley-type dependence of the collector current on...