[Clinical characteristics and risk factors for feeding intolerance in preterm infants]

Xi Huang1, Qiong Chen1, Wentao Peng2

  • 1Department of Neonatology; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu 610041, China.

Insights

Feeding intolerance (FI) affects over half of preterm infants, with higher incidence in females and extremely low birth weight infants. Key risk factors include low birth weight, caffeine citrate use, and formula feeding.

Area of Science:

  • Neonatology
  • Pediatric Gastroenterology
  • Clinical Nutrition

Background:

  • Feeding intolerance (FI) is a common complication in preterm infants, impacting growth and increasing healthcare costs.
  • Early identification and management of FI are crucial for improving outcomes in this vulnerable population.

Purpose of the Study:

  • To investigate the clinical characteristics and risk factors associated with feeding intolerance in preterm infants.
  • To provide evidence for the early identification, effective prevention, and treatment of FI in preterm neonates.

Main Methods:

  • A cohort of 116 preterm infants was observed in a Neonatology department.
  • Clinical data, including feeding intolerance symptoms and risk factors, were collected using a designed observation table.
  • Logistic multivariate regression analysis was employed to identify significant risk factors.

Main Results:

  • The incidence of feeding intolerance was 53.45%, with higher rates in females and extremely low birth weight infants.
  • Abdominal distension was the most common clinical manifestation, occurring primarily within 48-72 hours of feeding.
  • Significant risk factors identified were birth weight <1000g, caffeine citrate administration, and formula feeding.

Conclusions:

  • Feeding intolerance is highly prevalent in preterm infants.
  • Low birth weight (<1000g), caffeine citrate, and formula feeding are identified as primary risk factors for FI.
  • These findings underscore the need for targeted interventions to mitigate FI in high-risk preterm infants.
Abstract

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