Related Experiment Video

Updated: Feb 6, 2026

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
09:19

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma

Published on: July 14, 2022

4.3K

Novel targeted treatment options for advanced cholangiocarcinoma

Amit Mahipal1, Anuhya Kommalapati2, Sri Harsha Tella2

  • 1a Department of Medical Oncology , Mayo Clinic , Rochester , MN , USA.

Expert Opinion on Investigational Drugs
|August 21, 2018
PubMed
Abstract

Insights

Targeted therapies offer new hope for advanced cholangiocarcinoma, a rare cancer. Research is exploring treatments for molecular alterations like FGFR2 fusions and IDH1/2 mutations to improve patient outcomes.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Therapeutics

Background:

  • Cholangiocarcinoma (bile duct cancer) has limited treatment options for advanced stages.
  • Tumor heterogeneity and rarity pose challenges for clinical trials and treatment development.
  • Recent advancements in understanding molecular pathogenesis are driving the development of targeted therapies.

Purpose of the Study:

  • To review current targeted therapeutic options for advanced cholangiocarcinoma.
  • To discuss future directions and emerging treatments for this rare cancer.

Main Methods:

  • Review of current literature on targeted therapies for cholangiocarcinoma.
  • Analysis of molecular alterations and their therapeutic implications.
  • Evaluation of ongoing clinical trials for advanced cholangiocarcinoma.

Main Results:

  • Targeting FGFR2 fusions, IDH1/2 mutations, and HER2 receptors shows promise.
  • Combination therapies including immunotherapy, targeted agents, and chemotherapy may improve outcomes.
  • Drugs targeting MEK, EGFR, KRAS, BRAF, ROS1 pathways, and neo-angiogenesis represent future treatment avenues.

Conclusions:

  • Targeted therapies represent a significant advancement in managing advanced cholangiocarcinoma.
  • Personalized treatment strategies based on molecular profiling are crucial for improving prognosis.
  • Further research and clinical trials are essential to realize the full potential of these novel therapies.
Keywords:
FGFRIDHTargeted therapycholangiocarcinomagemcitabine

More Related Videos

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease04:11

Endolymphatic Duct Blockage as a Surgical Treatment Option for Ménière's Disease

Published on: April 28, 2023

2.5K
Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method07:12

Individualized rTMS Treatment for Depression using an fMRI-Based Targeting Method

Published on: August 2, 2021

4.2K

Related Concept Videos

Overview of Advanced Functional Groups02:22

Overview of Advanced Functional Groups


Functional groups are groups of atoms with specific chemical properties that occur within organic molecules and are sometimes denoted as “R”. Functional groups can “functionalize” a compound by enabling it to adopt different physical and chemical properties.
Types of Advanced Functional Groups
The table below summarizes some of the major functional groups in organic chemistry.
30.1K
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
1.2K
Sample Preparation for Analysis: Advanced Techniques01:08

Sample Preparation for Analysis: Advanced Techniques

Accurate analysis of complex samples often requires advanced preparation techniques to achieve reliable and reproducible results. Samples containing inorganic or organic materials can be challenging to dissolve or decompose effectively. Standard sample preparation methods include acid digestion, fusion, dry ashing, and wet digestion.
Acid digestion with strong acids is commonly used to dissolve inorganic materials that are insoluble (do not dissolve) in water. This method can be useful for...
1.5K
Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques

Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
561
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.0K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K