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Related Experiment Video

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Focal Laser Ablation of Prostate Cancer: An Office Procedure
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Prostate focal therapy: the rule or exception?

Kae Jack Tay1

  • 1Department of Urology, Singapore General Hospital, SingHealth Duke-NUS Academic Medical Center, Singapore.

Current Opinion in Urology
|August 21, 2018
PubMed
Summary
This summary is machine-generated.

Focal therapy for prostate cancer offers a way to preserve function while treating cancer. Success requires expertise, but it can be a good option for select patients with careful monitoring.

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Area of Science:

  • Urology
  • Oncology
  • Medical Technology

Background:

  • Prostate focal therapy aims to treat localized prostate cancer while preserving urinary and sexual function.
  • This approach is considered for men with low-volume, organ-confined prostate cancer.
  • Systematic reviews are crucial for evaluating the efficacy and safety of emerging treatments.

Purpose of the Study:

  • To systematically review the current evidence on the efficacy and safety of prostate focal therapy.
  • To determine the potential for standard clinical application of focal therapy.
  • To assess the oncological outcomes and functional preservation associated with focal therapy.

Main Methods:

  • Systematic review of existing literature on prostate focal therapy.
  • Analysis of data on cancer progression, conversion to radical therapy, and oncological outcomes.
  • Evaluation of complication rates, urinary continence, and erectile function post-treatment.

Main Results:

  • Focal therapy can reduce cancer progression and the need for radical treatment in men on active surveillance.
  • Success is contingent on advanced imaging and targeted biopsies, with a risk of under-detection.
  • The complication rate is low, with minimal impact on urinary continence and moderate impact on erectile function.

Conclusions:

  • Focal therapy is a viable option for carefully selected men with low-intermediate risk prostate cancer, prioritizing functional preservation.
  • Expertise in imaging, biopsy, and ablation is essential for successful outcomes.
  • Patients must accept the need for close post-treatment surveillance and the potential for future whole-gland therapy.