Related Experiment Video
Updated: Feb 6, 2026

Chronic Social Defeat Stress in Early Adolescent Male Mice
Published on: January 24, 2025
Clinical research with adolescents: barriers and how to overcome them
1Navicent Health Department of Obstetrics and Gynecology, Mercer University School of Medicine, Macon, Georgia.
Purpose Of Review:
This review aims to emphasize the importance of including adolescents in research, outline current standards and evaluate barriers that prevent adolescent research. We also hope to provide some guidance and call for much needed additional direction in the field.
Recent Findings:
The absolute necessity for including adolescents in research has been an area of focus within the community of adolescent providers and care takers. Recent policy and support from major organizations has emphasized the importance of including this population in research but also pointed out many of the complexities.
Summary:
Adolescent research is imperative to guiding policy and promoting evidence-based care. Current standards provide both guidance and barriers, yet more research is needed to further guide conduct of ethical research in this population.
Related Concept Videos
Cognitive Development During Adolescence
Revisionist Views of Adolescent and Adult Cognition
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems
Physiological Barriers
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
Erikson's Theory on Socioemotional Development during Adolescence
Mucosal Barrier of the Stomach
Within parietal cells, carbonic acid is first formed through the reaction of water and carbon dioxide. The dissociation of carbonic acid releases bicarbonate and hydrogen ions. The bicarbonate...

