Related Experiment Video
Updated: Feb 6, 2026

Murine Model of Leukemia Relapse to Induction Chemotherapy for Acute Lymphoblastic Leukemia
Published on: October 17, 2025
P-glycoprotein Activity Correlates With Treatment Response in 2 Leukemia Child Patients
María J Muñoz-Pérez1, Stephania Casco2, María D C Garza-González3
1Medicine School, Anáhuac University.
Monitoring P-glycoprotein (P-gp) activity in childhood acute lymphoblastic leukemia is crucial. Increased P-gp activity correlates with disease progression and poor prognosis, highlighting its role in treatment resistance and patient survival.
Area of Science:
- Pediatric Oncology
- Hematology
- Cancer Biology
Background:
- Acute lymphoblastic leukemia (ALL) is a leading childhood cancer.
- Multidrug resistance (MDR) significantly impacts treatment outcomes and prognosis in ALL.
- P-glycoprotein (P-gp) is a key efflux pump implicated in MDR.
More Related Videos
09:01Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
Published on: March 26, 2018
06:48In Ovo Xenografting of Patient-Derived Acute Lymphoblastic Leukemia (ALL) Cells (PDX-ALL)
Published on: August 1, 2025
Related Concept Videos
Correlations
Correlation and Causation
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
Matrix Proteoglycans and Glycoproteins
Correlation
Two variables, for example, a and b, are said to be positively correlated if both variables move in the same direction. In other words, a positive correlation exists between two variables, a and b, if:
Correlation and Regression
Coefficient of Correlation
If you suspect a linear relationship between x and y, then r can measure how strong the linear relationship is.
What the VALUE of r tells us:
The value of r is always between –1 and +1: –1 ≤ r ≤ 1.
The size of the correlation r indicates the...