Related Experiment Video
Updated: Feb 6, 2026

The Use of the Puzzle Box as a Means of Assessing the Efficacy of Environmental Enrichment
Published on: December 29, 2014
What Lies Beneath the Face Value of a BOX WARNING: A Deeper Look at Brodalumab
Abstract:
Brodalumab, a fully human antibody of the interleukin-17 receptor, is highly effective in the treatment of moderate-to-severe plaque psoriasis. However, based on safety signals identified in clinical trials, brodalumab carries a boxed warning regarding possible risks of suicidal ideation and behavior (SIB). The validity of this link remains controversial, especially in the context of the psoriasis population as well as clinical trial data from other recently approved treatments. Herein, we critically examine the association between brodalumab and SIB. J Drugs Dermatol. 2018;17(8 Suppl):s29-34.
Related Concept Videos
Microsoft Excel: Median, Quartile range, and Box Plots
Median and Quartile Range: The median is calculated using the formula `=MEDIAN(range)', which provides the middle value of your data set. Quartiles divide your data into four equal parts. To find the first and third quartiles, use ‘=QUARTILE(range, 1)' and ‘=QUARTILE(range, 3)', respectively. The interquartile range (IQR), which...
Predator-Prey Interactions
What is Behavior?
Group Polarization
Case Studies
Tissues

