Related Experiment Videos
Fatal adenovirus pneumonia in two newborn infants, one case caused by adenovirus type 30
Abstract:
Adenovirus rarely causes pneumonia in the newborn infant. We added 2 cases of fatal adenovirus neonatal pneumonia to the 3 cases previously reported. One of our cases was caused by adenovirus type 30, which is not previously known to be a pathogen. While the pneumonia could have been acquired in the nursery, the presence of chorioamnionitis and mixed infection with group B beta-hemolytic streptococcus suggests that an ascending infection from the birth canal might be another mode of transmission for neonatal adenovirus pneumonia.
Insights
Neonatal adenovirus pneumonia is rare but can be fatal. New cases, including one from adenovirus type 30, suggest ascending infection from the birth canal as a possible transmission route.
Area of Science:
- Pediatric Infectious Diseases
- Virology
- Neonatal Medicine
Background:
- Adenovirus infections are uncommon causes of pneumonia in newborns.
- Fatal neonatal adenovirus pneumonia is a rare but severe clinical presentation.
Observation:
- Two new fatal cases of adenovirus neonatal pneumonia were documented.
- One case involved adenovirus type 30, a previously unrecognized pathogen in this context.
Findings:
- Adenovirus type 30 identified as a potential pathogen in neonatal pneumonia.
- Chorioamnionitis and concurrent group B beta-hemolytic streptococcus infection were noted in one case.
Implications:
- Ascending infection from the birth canal is a potential transmission route for neonatal adenovirus pneumonia.
- Increased awareness and diagnostic considerations for adenovirus, including novel types, are warranted in neonatal pneumonia cases.