The Clinical-Translational Physician-Scientist: Translating Bedside to Bench

Translational research is often conceptualized with an implicit directionality, taking an idea generated in the laboratory (ie, the "bench") and applying it at the point of care (ie, the "bedside"). This role is often played by physician-scientists who work both in the laboratory and in the clinic. Less well appreciated is the valuable role a physician-scientist can play by using compelling observations from clinical research studies to guide basic scientists toward clinically important problems and even novel scientific concepts. The goal of this editorial is to highlight this often overlooked role that clinical-translational physician-scientists can play in translating observations at the bedside to efforts at the bench, highlighting their importance for scientific progress and discussing the type of research training and scientific environments that can help these individuals flourish. The importance of cohort studies and multidisciplinary team science in this context will also be highlighted.