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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
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Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Feb 6, 2026

Establishment of Epstein-Barr Virus Growth-transformed Lymphoblastoid Cell Lines
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Epstein-Barr Virus and Cancer.

Paul J Farrell1

  • 1Section of Virology, Imperial College Faculty of Medicine, London W2 1PG, United Kingdom;

Annual Review of Pathology
|August 21, 2018
PubMed
Summary

Epstein-Barr virus (EBV) drives 1.5% of human cancers by promoting B lymphocyte proliferation. Understanding EBV

Area of Science:

  • Virology
  • Oncology
  • Immunology

Background:

  • Epstein-Barr virus (EBV) is linked to approximately 1.5% of human cancers globally.
  • Viral gene expression occurs within malignant cells, indicating a direct role in cancer development.
  • EBV efficiently induces proliferation of infected human B lymphocytes.

Purpose of the Study:

  • To elucidate the functions of EBV proteins and small RNAs in cancer development.
  • To explore the impact of EBV genome sequence variation on its pathogenic roles.
  • To identify opportunities for early diagnosis, treatment, and prevention of EBV-associated cancers.

Main Methods:

  • Analysis of viral gene functions and their contribution to oncogenesis.
  • Investigation of EBV genome sequence variations.
Keywords:
EBNALMPgastric carcinomalymphomamiRNAnasopharyngeal carcinoma

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  • Review of current understanding of EBV-driven cancer mechanisms.

    • Main Results:

    • Functions of viral proteins and small RNAs contributing to EBV-associated cancers are becoming clearer.
    • Understanding EBV genome sequence variation aids in interpreting viral roles.
    • Improved knowledge of cancer mechanisms offers avenues for intervention.

    Conclusions:

    • Enhanced understanding of EBV's role in cancer facilitates early diagnosis and targeted immunotherapy.
    • Opportunities exist for disease prevention through immunization.
    • Development of therapeutic agents targeting EBV gene products in cancers is feasible.