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An in-vivo pilot study into the effects of FDG-mNP in cancer in mice

Omer Aras1, Gillian Pearce2, Adam J Watkins3,4

  • 1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States of America.

Plos One
|August 21, 2018
PubMed
Abstract

Insights

Fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) show promise for cancer treatment. Studies in mice indicate FDG-mNPs are safe when administered intravenously or intratumourally, with minimal effects on normal tissues.

Area of Science:

  • Nanomedicine
  • Oncology
  • Biomedical Engineering

Background:

  • Fluorodeoxy glucose conjugated magnetite nanoparticles (FDG-mNPs) are being explored for cancer therapy.
  • Magnetic hyperthermia combined with FDG-mNPs shows potential for cancer cell destruction.

Purpose of the Study:

  • To evaluate the safety and potential toxic effects of FDG-mNPs.
  • To assess FDG-mNP distribution in tumor-bearing and normal mice after intravenous or intratumoural administration.

Main Methods:

  • FDG-mNPs were synthesized and administered to prostate-tumor bearing mice and normal mice.
  • Histological analysis of various organs was performed at different time points post-injection.
  • Long-term organ retention of FDG-mNPs was investigated in normal mice.

Main Results:

  • FDG-mNPs concentrated in prostate tumors with minimal distribution to other organs.
  • FDG-mNP concentrations decreased over time in all examined tissues.
  • No detrimental effects were observed in normal mice at 3 or 6 months post-injection.

Conclusions:

  • Intravenous or intratumoural administration of FDG-mNPs appears safe for potential cancer therapy.
  • FDG-mNPs can be safely administered for effective cancer cell destruction.
  • Further research will explore hyperthermia in conjunction with FDG-mNPs in mice.

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