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Implementing a biogeographic ancestry inference service for forensic casework
Soulbee Jin1, Maretta Chase1, Margaret Henry1
1Centre of Forensic Sciences, Toronto, Canada.
Electrophoresis
|August 21, 2018
Summary
Forensic biogeographic ancestry inference using Massively Parallel Sequencing shows high correlation with declared ancestry. Reporting guidelines were developed to manage complex admixture predictions for casework implementation.
Area of Science:
- Forensic Science
- Genetics
- Bioinformatics
Background:
- The Centre of Forensic Sciences validated the Precision ID Ancestry Panel for forensic casework.
- Massively Parallel Sequencing (MPS) offers advanced genetic analysis capabilities.
Purpose of the Study:
- Develop reporting guidelines for biogeographic ancestry inference.
- Implement a service based on Admixture Prediction results for forensic casework.
Main Methods:
- Utilized the Ion S5™ MPS instrument and Torrent Suite™ Software.
- Employed an Admixture Prediction algorithm with seven root populations.
- Evaluated reporting guidelines with additional sample data.
Main Results:
- High correlation observed between declared and predicted ancestry for individuals with single ancestries.
- Admixture Predictions revealed complex ancestry in some individuals from Southern Europe, Southwest Asia, South Asia, and the Horn of Africa.
- Accurate identification of major ancestral components in individuals with known admixed ancestry.
Conclusions:
- Developed and evaluated reporting guidelines for biogeographic ancestry inference in forensic casework.
- The guidelines facilitate the implementation of ancestry prediction services.
- The study provides a framework for reporting complex genetic ancestry findings.
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