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Updated: Feb 6, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Canvassing the aetiology, prognosis and molecular signatures of obstructive sleep apnoea

Sartaj Khurana1, Shivani Sharda1, Biswajit Saha1

  • 1a Amity Institute of Biotechnology, Amity University , Noida , India.

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
|August 22, 2018
PubMed
Abstract

Insights

Obstructive sleep apnoea (OSA) involves complex molecular changes. Research highlights microRNAs, epigenetics, and SNPs as key players in OSA prognosis and potential diagnostic biomarkers.

Area of Science:

  • Sleep Medicine
  • Molecular Biology
  • Genetics

Background:

  • Obstructive sleep apnoea (OSA) is a prevalent sleep disorder linked to significant cardiovascular and metabolic health risks.
  • Understanding the pathophysiology of OSA is crucial for public health due to its associated morbidities.

Purpose of the Study:

  • To review and synthesize clinico-molecular analyses of microRNAs, single-nucleotide polymorphisms (SNPs), transcriptome profiles, and epigenetics in OSA prognosis.
  • To identify key regulatory molecules, such as microRNAs, contributing to OSA clinical outcomes.

Main Methods:

  • A comprehensive literature survey was conducted.
  • Data was retrieved from prominent scientific databases including Google Scholar, PubMed, and Science Direct.

Main Results:

  • Existing research identifies biomarkers like CRP, TNF-α, IL-6, IL-8, and CAMs in OSA.
  • However, the role of epigenetics in OSA pathophysiology remains an area of ongoing investigation and speculation.

Conclusions:

  • MicroRNA profiling, transcriptome analysis, DNA methylation, and SNPs represent under-explored areas crucial for understanding OSA molecular mechanisms.
  • Epigenetic regulators are emerging as promising biomarkers for OSA diagnosis, advancing the search for reliable diagnostic tools.
Keywords:
Obstructive sleep apnoeabiomarkerscardiovascular diseaseepigeneticsinflammatory factorsobesity

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