Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

1.9K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
1.9K
Induced-fit Model01:13

Induced-fit Model

89.4K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
89.4K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.1K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.1K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.6K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.6K
Induced Electric Dipoles01:28

Induced Electric Dipoles

4.8K
A permanent electric dipole orients itself along an external electric field. This rotation can be quantified by defining the potential energy because the external torque does work in rotating it. Then, the potential energy is minimum at the parallel configuration and maximum at the antiparallel configuration. While the former is a stable equilibrium, the latter is an unstable equilibrium.
Since the absolute value of potential energy holds no physical meaning, its zero value can be chosen as per...
4.8K
Induced Electric Fields01:23

Induced Electric Fields

4.6K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Controlled Use of Cannabis Among Young Adults in Los Angeles Across Changes in Cannabis Policies.

International journal of mental health and addiction·2026
Same author

Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios Predict Improved Survival and Response to Induction Chemotherapy in Locally Advanced Squamous Cell Carcinoma of the Larynx.

Head & neck·2025
Same author

FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial.

Clinical cancer research : an official journal of the American Association for Cancer Research·2025
Same author

Identifying Three Psilocybin Use Patterns by Frequency and Quantity.

Journal of studies on alcohol and drugs·2024
Same author

Follow-up for human papillomavirus-related oropharynx cancer concentrated on unequal symptom change (FOCUS): Prospective patient-reported outcome collection.

Head & neck·2024
Same author

Enhanced Care Units: Guidance on development and implementation within Acute Medicine.

Acute medicine·2023

Related Experiment Video

Updated: Feb 6, 2026

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.7K

Heparin-induced thrombocytopaenia.

Mark Prince1, Tim Wenham2

  • 1ST4 in Anaesthesia and Intensive Care, Barnsley Hospital NHS Foundation Trust, Barnsley, UK markprince571@gmail.com.

Postgraduate Medical Journal
|August 22, 2018
PubMed
Summary

Heparin-induced thrombocytopaenia (HIT) is a serious adverse drug reaction causing hypercoagulability and thrombosis. Prompt diagnosis and alternative anticoagulation are crucial for managing HIT patients.

Keywords:
anticoagulationhaematologyimmunology

More Related Videos

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
10:41

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity

Published on: February 17, 2017

8.5K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

8.1K

Related Experiment Videos

Last Updated: Feb 6, 2026

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.7K
Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity
10:41

Using a GFP-tagged TMEM184A Construct for Confirmation of Heparin Receptor Identity

Published on: February 17, 2017

8.5K
Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

8.1K

Area of Science:

  • Pharmacology
  • Hematology
  • Immunology

Background:

  • Heparin-induced thrombocytopaenia (HIT) is a severe, life-threatening adverse drug reaction.
  • HIT leads to extreme hypercoagulability, increasing risks of life- and limb-threatening thrombosis.
  • The condition has a significant mortality rate of 5%-10%.

Purpose of the Study:

  • To outline the diagnostic and management strategies for Heparin-induced thrombocytopaenia (HIT).
  • To emphasize the critical need for early recognition and intervention in HIT cases.

Main Methods:

  • Diagnosis relies on a high index of clinical suspicion.
  • Utilizes validated scoring systems for HIT risk assessment.
  • Confirms diagnosis through specific laboratory testing.

Main Results:

  • HIT is an antibody-mediated process triggering platelet activation.
  • Immediate cessation of heparin and low-molecular-weight heparin is mandatory.
  • Alternative anticoagulants like argatroban or danaparoid are essential treatments.

Conclusions:

  • Prompt diagnosis and management of HIT are critical to prevent severe thrombotic complications.
  • Alternative anticoagulation strategies are vital for patients with suspected or confirmed HIT.
  • Fondaparinux may be considered, though not officially licensed for HIT treatment.