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Updated: Feb 6, 2026

A Filtration-based Method of Preparing High-quality Nuclei from Cross-linked Skeletal Muscle for Chromatin Immunoprecipitation
Published on: July 6, 2017
Pore cross-talk in colloidal filtration
Olivier Liot1,2,3, Akash Singh4, Patrice Bacchin5
1LAAS-CNRS, Université de Toulouse, CNRS, Toulouse, France. olivier.liot@ens-lyon.fr.
Abstract:
Blockage of pores by particles is found in many processes, including filtration and oil extraction. We present filtration experiments through a linear array of ten channels with one dimension which is sub-micron, through which a dilute dispersion of Brownian polystyrene spheres flows under the action of a fixed pressure drop. The growth rate of a clog formed by particles at a pore entrance systematically increases with the number of already saturated (entirely clogged) pores, indicating that there is an interaction or "cross-talk" between the pores. This observation is interpreted based on a phenomenological model, stating that a diffusive redistribution of particles occurs along the membrane, from clogged to free pores. This one-dimensional model could be extended to two-dimensional membranes.
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