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Technique for Intranasal Administration of α-Synuclein Aggregates
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α-Synuclein interacts directly but reversibly with psychosine: implications for α-synucleinopathies

Hazem Abdelkarim1, Michael S Marshall2, Giuseppe Scesa2

  • 1Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60607, USA.

Scientific Reports
|August 22, 2018
PubMed
Summary

Lysosomal dysfunction in Krabbe disease causes psychosine accumulation, promoting alpha-synuclein aggregation. Correcting this deficiency or using small molecules like dopamine can prevent aggregation, offering therapeutic strategies for synucleinopathies.

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