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Isolation of Myoepithelial Cells from Adult Murine Lacrimal and Submandibular Glands
Published on: June 11, 2019
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Epithelial-myoepithelial carcinoma: a population-based survival analysis
1Department of Otolaryngology, SUNY Upstate Medical University, Physicians Office Building North, Suite 4P, 4900 Broad Road, Syracuse, NY 13215 USA.
BMC Ear, Nose, and Throat Disorders
|August 22, 2018
Summary
Epithelial-myoepithelial carcinoma, a rare salivary gland tumor, shows improved survival with early diagnosis and treatment. Factors like age, race, and cancer stage significantly impact patient outcomes.
Area of Science:
- Oncology
- Pathology
- Epidemiology
Background:
- Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland malignancy, accounting for 1-2% of all salivary gland tumors.
- Fewer than 600 cases have been documented since its initial description in 1972.
Purpose of the Study:
- To investigate demographic, site, stage, and survival factors in patients diagnosed with EMC.
- To analyze survival rates and influencing factors for this uncommon cancer.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1973-2014) to identify EMC patients.
- Analyzed patient data including tumor (T), nodal (N), and metastasis (M) stage, tumor site, and demographics.
- Employed the Kaplan-Meier model for actuarial survival estimation.
Main Results:
- A total of 468 patients were identified; 78% were White, and 291 were female.
- The parotid gland was the most common primary site (57.7%). Overall 5-, 10-, and 20-year survival rates were 72.7%, 59.5%, and 38.3%, respectively.
- Univariate and multivariate analyses indicated that age, race, AJCC stage, T, N, M stage, and treatment type significantly impacted survival.
Conclusions:
- EMC is a malignant biphasic neoplasm predominantly found in the parotid gland with low rates of nodal and distant metastasis.
- Survival is significantly influenced by age at diagnosis, race, cancer staging (AJCC, T, N, M), and treatment modality.
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