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Functions of the Nervous System

Functions of the Nervous System

The nervous system is responsible for coordinating and regulating the body's functions. It functions through three main processes: sensory, integrative, and motor processes. Sensory function involves the detection and transmission of information about internal and external stimuli from sensory receptors to the CNS. The CNS processes this information through an integrative function, where it interprets and makes decisions based on the incoming sensory information. Finally, the motor function...

Functional Divisions of the Nervous System

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The nervous system, responsible for sensing, integrating, and responding to various stimuli, is divided into the central nervous system (CNS) and the peripheral nervous system (PNS). The PNS has two functional divisions: the sensory or afferent division and the motor or efferent division.
The sensory division transmits information from sensory receptors in the body to the CNS. It provides the CNS with knowledge about somatic senses (such as tactile, thermal, pain, and proprioceptive sensations)...

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Ole Isacson: Development of New Therapies for Parkinson's Disease

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Nuclear Architecture in the Nervous System: Development, Function, and Neurodevelopmental Diseases.

Kenji Ito^1,2, Takumi Takizawa¹

¹Department of Pediatrics, Graduate School of Medicine, Gunma University, Maebashi, Japan.

Frontiers in Genetics

|August 22, 2018

Summary

Nuclear architecture, involving chromatin and nuclear bodies, is crucial for neural development and function. Understanding these epigenetic mechanisms in neurons offers insights into learning, memory, and neurological diseases.

Keywords:

chromatin development differentiation epigenetics gene positioning glia neuron nuclear architecture

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Area of Science:

Neuroscience
Epigenetics
Cell Biology

Background:

Epigenetic regulation is vital for neural development and function.
The eukaryotic cell nucleus comprises chromatin, architectural proteins, and nuclear bodies, collectively termed nuclear architecture.
Nuclear architecture dynamically rearranges to alter transcription programs in the nervous system.

Purpose of the Study:

To review recent research on nuclear architecture in the nervous system.
To discuss the importance of nuclear architecture in neural development, maturation, function, and disease.

Main Methods:

Review of existing scientific literature on nuclear architecture and epigenetics in the nervous system.

Main Results:

Dynamic rearrangement of neuronal nuclear architecture correlates with altered gene expression.
Changes in nuclear architecture are essential for specialized neuronal functions like learning and memory.
Neuronal nuclear architecture is distinct among cell types and may involve cell-division-independent mechanisms.

Conclusions:

Nuclear architecture plays a significant role in the nervous system's development, maturation, and function.
Further study of neuronal nuclear architecture can reveal novel insights into neurological disorders.