Anti-inflammatory and antitumor action of hydrogen via reactive oxygen species

Hydrogen (H₂) has advantages that lead it to be used as a novel antioxidant in preventive and therapeutic applications. H₂ can permeate into biomembranes, cytosol, mitochondria and nuclei, and can be dissolved in water or saline to produce H₂ water or H₂-rich saline. H₂ selectively reduces oxidants of the detrimental reactive oxygen species (ROS), including hydroxyl radicals (·OH) and peroxynitrite (ONOO^-), which serve a causative role in the promotion of tumor cell proliferation, invasion and metastasis, but do not disturb metabolic oxidation-reduction reactions in cell signaling. Compared with traditional antioxidants, H₂ is a small molecule that can easily dissipate throughout the body and cells; thus, it may be a safe and effective antioxidant for inflammatory diseases and cancer, since ROS usually initiates tumor progression. Treatment with H₂ may involve correction of the oxidative/anti-oxidative imbalance and suppression of inflammatory mediators. Therefore the present review will discuss the anti-inflammatory and anti-tumorigenic action of H₂ via ROS.