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Updated: Feb 6, 2026
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
Published on: March 14, 2014
Overexpression of TPX2 is associated with progression and prognosis of prostate cancer
Jun Zou1, Rui-Yan Huang2, Fu-Neng Jiang3
1Department of Emergency Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Abstract:
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) activates Aurora kinase A during mitosis and targets its activity to the mitotic spindle, serving an important role in mitosis. It has been associated with different types of cancer and is considered to promote tumor growth. The aim of the present study was to explore the role of TPX2 in diagnosing prostate cancer (PCa). It was identified that TPX2 expression in PCa tissues was increased compared with benign prostate tissues. Microarray analysis demonstrated that TPX2 was positively associated with the Gleason score, tumor-node-metastasis (TNM) stage, clinicopathological stage, metastasis, overall survival and biochemical relapse-free survival. In vitro studies revealed that the high expression of TPX2 in PCa cells improved proliferative, invasive and migratory abilities, and repressed apoptosis of the PCa cells, without affecting tolerance to docetaxel. The results suggested that TPX2 serves as a tumorigenesis-promoting gene in PCa, and a potential therapeutic target for patients with PCa.
Insights
Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is elevated in prostate cancer (PCa), promoting tumor growth and metastasis. High TPX2 expression correlates with advanced disease and poor survival, suggesting it as a potential therapeutic target.
Area of Science:
- Molecular Biology
- Oncology
- Cell Biology
Background:
- Targeting protein for Xenopus kinesin-like protein 2 (TPX2) is crucial for Aurora kinase A activation during mitosis.
- TPX2 overexpression is linked to various cancers and tumor progression.
Purpose of the Study:
- To investigate the role of TPX2 in the diagnosis and progression of prostate cancer (PCa).
Main Methods:
- Comparative analysis of TPX2 expression in PCa versus benign prostate tissues.
- Microarray analysis to correlate TPX2 levels with clinicopathological features.
- In vitro studies to assess the functional impact of TPX2 on PCa cell behavior.
Main Results:
- TPX2 expression is significantly higher in PCa tissues than in benign tissues.
- TPX2 levels positively correlate with Gleason score, TNM stage, metastasis, and survival outcomes.
- High TPX2 expression enhances PCa cell proliferation, invasion, and migration while inhibiting apoptosis, independent of docetaxel sensitivity.
Conclusions:
- TPX2 acts as a tumor-promoting gene in prostate cancer.
- TPX2 represents a potential diagnostic biomarker and therapeutic target for PCa.
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