Wnt2 contributes to the progression of gastric cancer by promoting cell migration and invasion
Related Experiment Video
Updated: Feb 6, 2026

Impedance-based Real-time Measurement of Cancer Cell Migration and Invasion
Published on: April 2, 2020
Zhaoran Zhang1, Jinyan Wang2, Xiang Dong1
1Department of Gastroenterology, Jining First People's Hospital, Jining, Shandong 272000, P.R. China.
Abstract:
Wnt2 plays a pivotal role in human cancer. However, it is not yet known whether Wnt2 contributes to promoting migration and invasion of gastric cancer. The present study aimed to investigate the expression of Wnt2 in gastric cancer tissues and cell lines, and to analyze the effect of Wnt2 on gastric cancer cells. Wnt2 expression level was evaluated in gastric cancer samples and adjacent normal gastric tissues by immunohistochemical and western blot analysis. To investigate the effect of Wnt2 on gastric cancer cells, an in vitro Wnt2 secreting system was established using CHO cells. The results indicated that Wnt2 is overexpressed in gastric cancer and is implicated in metastasis and TNM stage. Additionally, the results of in vitro experiments demonstrated that Wnt2 contributes to enhancing the migration and invasion abilities of gastric cancer cells. These results suggested that Wnt2 may be an effective target of treatment for patients with advanced gastric cancer.
Related Concept Videos
Cancer Cell Migration through Invadopodia
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Cell Migration
Cell Migration
The Eukaryotic Promoter Region
Binet's Contribution to Measures of Intelligence

