Related Experiment Video

Updated: Feb 6, 2026

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer
04:20

Author Spotlight: Exploring the Role of FAM83A in Cervical Cancer

Published on: February 9, 2024

1.5K

Role of YAP in lung cancer resistance to cisplatin

Juan Song1, Li-Xia Xie1, Xin-Yi Zhang1

  • 1Department of Respiratory Diseases, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

Oncology Letters
|August 22, 2018
PubMed

Insights

Yes-associated protein (YAP) drives chemoresistance in lung cancer stem cells. Targeting YAP may enhance chemotherapy effectiveness for lung cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Stem Cell Research

Background:

  • Yes-associated protein (YAP) is implicated in cancer progression and drug resistance.
  • The role of YAP in lung cancer stem cell (LCSC) chemoresistance is not well understood.

Purpose of the Study:

  • To investigate the role of YAP in cisplatin resistance in LCSCs.
  • To evaluate YAP targeting as a potential therapeutic strategy for lung cancer.

Main Methods:

  • Established lung cancer spheres from A549 cells to model LCSCs.
  • Assessed YAP expression and its correlation with cisplatin (CDDP) resistance.
  • Performed YAP knockdown experiments to determine its effect on CDDP sensitivity.

Main Results:

  • YAP was overexpressed in lung cancer spheres compared to adherent cells.
  • Overexpressed YAP was associated with enhanced CDDP resistance.
  • YAP knockdown sensitized both adherent cells and spheres to CDDP, increasing cell death.

Conclusions:

  • YAP plays a significant role in LCSC-mediated chemoresistance.
  • Targeting YAP could be a promising adjuvant therapy to improve chemotherapy outcomes in lung cancer.
Keywords:
Yes-associated proteinchemoresistancecisplatinlung cancer stem cell

More Related Videos

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

11.0K
Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis07:47

Studying the Role of Alveolar Macrophages in Breast Cancer Metastasis

Published on: June 26, 2016

10.2K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.8K
Lung Capacity01:47

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.
56.4K
Resistivity01:22

Resistivity

When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.6K
Resistance01:19

Resistance

When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
6.0K
Role of Septins01:02

Role of Septins

Septins are the recently discovered fourth major protein component of the cytoskeleton, along with microfilaments, microtubules, and intermediate filaments. These proteins can associate with other cytoskeletal filaments and carry out varied roles or can be free-floating in the cytoplasm.
Cellular Functions of Septins
Recent studies have revealed the multifaceted roles of septins in various cellular processes such as cytokinesis, ciliogenesis, and neurogenesis. Septins act as scaffolds and...
2.2K
Equivalent Resistance01:16

Equivalent Resistance

In circuit analysis, situations often arise where resistors are neither in series nor parallel configurations. To tackle such scenarios, three-terminal equivalent networks like the wye (Y) (Figure 1 (a)) or tee (T) and delta (Δ) (Figure 1 (b)) or pi (π) networks come into play. These networks offer versatile solutions and are frequently encountered in various applications, including three-phase electrical systems, electrical filters, and matching networks.
987