Multi-focal, multi-centric granular cell tumours: a management dilemma

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Granular cell tumours (GCT) are uncommon neoplasms typically of neural/Schwann cell origin.
• They usually present as solitary, indolent lesions, with excision as the standard treatment.
• Malignancy is primarily indicated by distant or nodal metastases.

Observation:

• A 47-year-old woman presented with a rare multi-focal, multi-centric GCT.
• The tumour involved multiple organ systems, including the pulmonary and gastrointestinal tracts.
• Imaging and pathological features presented diagnostic challenges.

Findings:

• The case demonstrated an unusual presentation of GCT with widespread involvement.
• Establishing the malignant potential of this multi-focal GCT was complex.
• The findings underscore the variability in GCT behaviour.

Implications:

• This case highlights the importance of comprehensive evaluation for GCT, especially in multi-focal presentations.
• It emphasizes the diagnostic challenges in differentiating benign from malignant GCTs.
• Further research into GCT behaviour and diagnostic markers may be warranted.