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Related Concept Videos

Therapeutic Index01:13

Therapeutic Index

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The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
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Potential Energy00:52

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The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
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On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
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Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
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Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
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Three-dimensional comparison of mandibular shape variability across skeletal classes: Cross-sectional geometric morphometric study.

American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics·2025
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Quantitative assessment of the temporomandibular joints in patients with osteogenesis imperfecta: a CBCT study.

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An Efficient and Reproducible Protocol for Distraction Osteogenesis in a Rat Model Leading to a Functional Regenerated Femur
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Osteogenesis imperfecta: potential therapeutic approaches.

Maxime Rousseau1, Jean-Marc Retrouvey2,

  • 1Faculty of Dentistry, McGill University, Montreal, QC, Canada.

Peerj
|August 22, 2018
PubMed
Summary

Osteogenesis imperfecta (OI) dental care requires special considerations due to collagen type I production issues. This guide offers evidence-based recommendations for managing dentoalveolar challenges in OI patients.

Keywords:
BisphosphonatesCrownsDentinogenesis imperfectaGeneticsOrthodonticOrthodonticsOsteogenesis imperfectaOsteonecrosis of the jawRare bone diseaseSurgery

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Area of Science:

  • Dental Medicine
  • Genetics
  • Orthodontics

Background:

  • Osteogenesis imperfecta (OI) is a genetic disorder impacting collagen type I production.
  • OI presents unique challenges for dental practitioners due to varying severity.
  • Specific dentoalveolar problems are common in individuals with OI.

Purpose of the Study:

  • To provide evidence-based guidelines for dental practitioners caring for OI patients.
  • To address the specific dentoalveolar issues encountered in OI.
  • To optimize diagnosis and treatment strategies for OI patients.

Main Methods:

  • Literature review of current scientific evidence.
  • Analysis of recommended dental treatments for primary and permanent dentitions.
  • Evaluation of orthodontic and surgical interventions in OI.

Main Results:

  • Full-coverage restorations (stainless steel or zirconia crowns) are recommended for primary and permanent teeth.
  • Intracoronal restorations should be avoided to prevent structural tooth loss.
  • Simple extractions are permissible, avoiding timing around bisphosphonate infusions; clear aligners are a viable orthodontic option.
  • Orthognathic surgery is discouraged in severe OI types (III, IV).

Conclusions:

  • A prudent, individualized approach is crucial for managing OI patients.
  • Treatment decisions depend on preliminary examination and clinical judgment.
  • A multidisciplinary team approach is favored for severe OI cases to optimize care.