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Vitamin B6 blood concentrations in paediatric dialysis patients

Triona Joyce1, Frances Court Brown1, Shazia Adalat2

  • 1Department of Nutrition and Dietetics, Evelina London Children's Hospital, Guys & St Thomas' NHS Foundation Trust, 3rd Floor Becket House, Westminster Bridge Road, SE1 7EH, London, UK.

Pediatric Nephrology (Berlin, Germany)
|August 22, 2018
PubMed

Insights

No vitamin B6 deficiency was found in children on long-term dialysis. However, over 50% had elevated levels, suggesting routine supplementation is not needed unless dietary intake is insufficient.

Area of Science:

  • Pediatric Nephrology
  • Clinical Nutrition
  • Biochemistry

Background:

  • Children on long-term dialysis may have altered nutritional status.
  • Vitamin B6 (pyridoxine) is essential for various metabolic processes.
  • Monitoring vitamin B6 levels is important in pediatric chronic kidney disease patients.

Purpose of the Study:

  • To investigate vitamin B6 blood concentrations in children undergoing long-term dialysis.
  • To determine the prevalence of vitamin B6 deficiency or elevation in this population.
  • To assess the need for routine vitamin B6 supplementation in pediatric dialysis patients.

Main Methods:

  • Retrospective cross-sectional review of 28 children on maintenance dialysis (peritoneal dialysis and intermittent hemodialysis).
  • Analysis of vitamin B6 blood concentrations measured at a median of 9 months post-dialysis initiation.
  • Comparison of vitamin B6 levels between PD and IHD groups.

Main Results:

  • No vitamin B6 deficiency was observed in any child.
  • Elevated vitamin B6 concentrations were found in 61% of the children.
  • Children receiving enteral feeds or supplements showed varied vitamin B6 levels; normal levels were maintained in some without supplementation.

Conclusions:

  • Routine vitamin B6 supplementation and monitoring are not currently indicated for children on chronic dialysis.
  • Measurement of blood vitamin B6 concentrations may be considered if dietary assessment suggests insufficient intake.
  • Further research could explore the long-term implications of elevated vitamin B6 in this cohort.
Abstract

Keywords:
Blood monitoringDialysisNutritionPyridoxineSupplementation

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