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Introduction to Techniques and Methodologies for Characterizing the Human Respiratory Virome
Alicia B Mitchell1,2,3, Allan R Glanville4
1The Woolcock Institute of Medical Research, Sydney, NSW, Australia. amit9422@uni.sydney.edu.au.
Methods in Molecular Biology (Clifton, N.J.)
|August 22, 2018
Summary
Advances in detection methods reveal a diverse human respiratory virome, challenging old beliefs about sterile lower airways. This research explores the clinical impact and diagnostic evolution of respiratory viruses.
Area of Science:
- Microbiology
- Virology
- Respiratory Medicine
Background:
- Historically, the lower respiratory tract was considered sterile.
- The detection of microbes was linked to host defense breaches and symptomatic infections.
- Recent advancements have overturned these long-held beliefs.
Purpose of the Study:
- To outline the clinical impact of the human respiratory virome.
- To discuss techniques for sampling the lower respiratory tract.
- To review the evolution of diagnostic tools for respiratory viruses.
Main Methods:
- Molecular detection techniques.
- Sequencing-based methodologies.
- Improvements in accessibility and cost-effectiveness of diagnostic tools.
Main Results:
- The lower respiratory tract harbors an abundant and diverse ecosystem of viruses.
- New understanding of the human respiratory virome's impact.
Conclusions:
- The human respiratory virome is a rapidly growing area of research.
- Future growth depends on advanced methodologies and efficient tools.
- Continued research will refine our understanding of respiratory viral infections.
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