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Updated: Feb 6, 2026

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
Published on: March 29, 2018
Maternal vascular malperfusion of the placental bed
1Department of Pathology and Laboratory Medicine, NorthShore University HealthSystem, Evanston Hospital, Evanston, IL, USA.
Abstract:
Maternal vascular malperfusion (MVM) of the placental bed represents a recognizable pattern of placental injury related to altered uterine and intervillous blood flow. MVM consists of a constellation of placental pathologic findings seen in the maternal decidual vessels, reflecting abnormal spiral artery remodeling, as well as in the villous parenchyma, reflecting abnormalities in oxygenation and flow dynamics in the intervillous space. This review is dedicated to the gross pathology, microscopic pathology, updated terminology, and clinical implications of MVM.
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