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Updated: Aug 7, 2026
Assessing Neurodegenerative Phenotypes in Drosophila Dopaminergic Neurons by Climbing Assays and Whole Brain Immunostaining
Published on: April 24, 2013
Models of Parkinson's Disease with Special Emphasis on Drosophila melanogaster
Ambreen Fatima1, Smita Jyoti1, Yasir Hasan Siddique1
1Drosophila Transgenic Laboratory, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, India.
Background & Objective:
Parkinson's disease is the second most common neurodegenerative disorder affecting more than 1% of the population averaged 60 years of age. The majority of PD cases are sporadic and are probably caused by a combination of risk factors but 5-10% of the PD cases are familial. Due to the high degree of the gene, conservation in humans, mice and insects using an animal model system is a valuable approach to further elucidate the roles of the genes in PD.
Conclusion:
The present review highlights the models used to study PD symptoms with special emphasis on Drosophila.
