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Updated: Feb 6, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
Systematic review and network meta-analysis: effect of biologics on radiographic progression in rheumatoid arthritis
Erin Murray1, Alexandra Ellis1, Yekaterina Butylkova1
1Doctor Evidence, Santa Monica, CA, 90401, USA.
Aim:
To evaluate the comparative effectiveness of biologics in inhibiting radiographic progression among rheumatoid arthritis (RA) patients.
Materials & Methods:
Bayesian network meta-analysis of published trials investigating the USA FDA approved biologics treatment in RA patients, using methotrexate (MTX) as the reference comparator.
Results:
Nine trials met the inclusion criteria for base case analysis. Compared with MTX, most biologics (except golimumab) + MTX had significantly lower rates of radiographic progression at 1 year. Mean difference in radiographic progression rates between MTX monotherapy and biologics + MTX was highest for adalimumab + MTX (-3.8) and lowest for tocilizumab + MTX (-0.7). Inhibition of radiographic progression was sustained.
Conclusion:
Biologics inhibit radiographic progression in patients with RA at 1 year; however, published evidence beyond 1 year is limited.
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