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Updated: Feb 6, 2026

Use of Human Perivascular Stem Cells for Bone Regeneration
Published on: May 25, 2012
Comparison of Decellularized Cow and Human Bone for Engineering Bone Grafts with Human Induced Pluripotent Stem Cells
Martina Sladkova1, Jiayi Cheng1, Michael Palmer2
11 The New York Stem Cell Foundation Research Institute, New York, New York.
Impact Statement:
Decellularized tissue matrices are popular as scaffolding materials for tissue engineering application. However, it is unclear whether interspecies differences in tissue parameters influence the quality of tissue grafts that are engineered using human stem cells. In this study, decellularized cow and human bone scaffolds were compared for engineering bone grafts using human induced pluripotent stem cell-derived mesodermal progenitor cells and despite minor differences in architecture and mass composition, both scaffolds equally support cell viability and tissue mineralization. Decellularized cow bone scaffolds therefore represent a suitable and more affordable alternative for engineering human bone grafts for basic and applied research.
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