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Vitamin D status and premature adrenarche
Onur Akın1, Aysun Bideci1, Esra Döğer1
1Department of Pediatric Endocrinology, Faculty of Medicine, Gazi University, Ankara, Turkey.
Summary
Low vitamin D levels are linked to premature adrenarche (PA) in girls. Insulin resistance may play a role in this association, highlighting the importance of vitamin D status in early development.
Area of Science:
- Pediatric Endocrinology
- Nutritional Science
- Metabolic Disorders
Background:
- Vitamin D is crucial for calcium-phosphate homeostasis.
- Emerging evidence links vitamin D to chronic conditions like hyperandrogenism.
- The role of vitamin D in premature adrenarche (PA) requires further investigation.
Purpose of the Study:
- To examine the association between vitamin D status and premature adrenarche (PA).
- To explore the potential role of insulin resistance in this relationship.
Main Methods:
- A case-control study involving 71 girls with PA and 52 controls.
- Premature adrenarche defined as pubic/axillary hair before age 8.
- Measurements included bone age, anthropometrics, 25-hydroxyvitamin D (25(OH)D), and insulin resistance markers (HOMA-IR).
- Vitamin D insufficiency defined as 25(OH)D < 20 ng/mL.
Main Results:
- PA patients exhibited older bone age, higher BMI, HOMA-IR, and androgens compared to controls.
- Lower 25(OH)D levels were observed in PA patients.
- PA patients with vitamin D insufficiency had higher HOMA-IR and dehydroepiandrosterone sulfate.
- A negative correlation was found between 25(OH)D and HOMA-IR.
Conclusions:
- Low vitamin D status is associated with premature adrenarche.
- Insulin resistance appears to be a significant factor mediating the link between vitamin D and PA.
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