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Updated: Feb 6, 2026

Acute Kidney Injury Model Induced by Cisplatin in Adult Zebrafish
Published on: May 15, 2021
Whortleberry protects kidney against the cisplatin-induced nephrotoxicity: an experimental study
Huseyin Eren1, Hasan Riza Aydin2, Levent Tumkaya3
1a Urology Department , Recep Tayyip Erdogan University School of Medicine , Rize , Turkey.
Purpose:
This study investigated the antioxidant effects of whortleberry against cisplatin-induced nephrotoxicity in rats.
Material And Methods:
This study included 48 female Sprague-Dawley rats weighing 263.68 ± 8.29 g. The rats were divided into the following six groups, with eight rats in each group: control, ethanol control, whortleberry control, cisplatin control, 16 mg/kg cisplatin +100 mg/kg whortleberry, and 16 mg/kg cisplatin +200 mg/kg whortleberry groups. Biochemical analysis was performed by measuring total oxidant status and total antioxidant status, histopathological analysis was performed by calculating proximal and distal tubule areas (μm2), and immunohistochemical analysis was performed by determining anti-Caspase-3 immunostaining. Differences among the groups were examined using one-way analysis of variance, and p < .05 was considered statistically significant.
Results:
Cisplatin treatment decreased the total antioxidant status and increased the total oxidant status and Caspase-3 level. Moreover, it resulted in the dilatation, vacuolization and loss of tubular epithelial cells; and glomerular degeneration and edema in the kidney tissues (p < .05). Treatment with 100 and 200 mg whortleberries increased the total antioxidant status; decreased the total oxidant status and Caspase-3 level and ameliorated distal and proximal tubule degeneration, glomerular degeneration and edema in the kidney tissues (p < .05).
Conclusions:
Our results indicate that the antioxidant effects of the whortleberry decrease cisplatin-associated nephrotoxicity.
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