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Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid

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Processed amniotic membrane for conjunctival reconstruction in complex strabismus surgery.

Sabine Naxer¹, Maren Horn¹, Michael Schittkowski¹

¹a Section for Strabismus, Neuroophthalmology and Oculoplastics , Georg-August-Universitat Gottingen Universitatsmedizin , Gottingen , Germany.

|August 22, 2018

Summary

This summary is machine-generated.

Amniotic membrane grafts effectively treat restrictive strabismus and conjunctival scarring after eye muscle surgery. While generally safe, symblepharon is a potential complication requiring further investigation.

Keywords:

Amniotic membrane Graves ophthalmopathy restricitve conjunctiva restricitve strabismus strabismus surgery

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Area of Science:

Ophthalmology
Regenerative Medicine
Tissue Engineering

Background:

Amniotic membrane is utilized for ocular surface conditions like corneal ulcerations and chemical burns.
Limited data exists on long-term outcomes of amniotic membrane use for conjunctival replacement.
This study investigates its application in restrictive strabismus and conjunctival defects post-eye muscle surgery.

Purpose of the Study:

To evaluate the efficacy and outcomes of using amniotic membrane for conjunctival replacement in patients with restrictive strabismus or conjunctival problems.
To assess the long-term results of amniotic membrane grafts in complex ophthalmic surgeries.

Main Methods:

Retrospective case study of 32 patients treated with Ambio5® amniotic membrane between 2009 and 2015.
Inclusion criteria: use of amniotic membrane for conjunctival issues during or after complex eye muscle surgery.
Analysis of patient charts for functional and aesthetic outcomes, complications, and follow-up duration.

Main Results:

Seven patients with restrictive conjunctiva post-strabismus surgery received amniotic membrane grafts.
Mean follow-up was 32 months; most patients showed improvement in restrictive strabismus and scarring.
Three patients developed symblepharon, with one requiring revision.

Conclusions:

Commercially prepared amniotic membrane serves as a viable alternative graft for conjunctival replacement.
It effectively addresses restrictive strabismus, conjunctival scarring, and discomfort.
The increased risk of symblepharon with storable products warrants further research.