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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Skin Cancer01:30

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Related Experiment Video

Updated: Feb 6, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
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Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

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Iron and Cancer.

Suzy V Torti1, David H Manz1,2, Bibbin T Paul1

  • 1Department of Molecular Biology and Biophysics, University of Connecticut Health Center, Farmington, Connecticut 06030, USA;

Annual Review of Nutrition
|August 22, 2018
PubMed
Summary
This summary is machine-generated.

Iron plays a critical role in cancer biology, influencing tumor growth and metastasis. Targeting iron metabolism presents a promising therapeutic strategy for cancer treatment.

Keywords:
cancercarcinogenesiscell deathiron

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Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Iron is essential for cellular processes, but its dysregulation is linked to cancer development.
  • Epidemiological and experimental studies suggest a strong association between iron and cancer incidence, initiation, growth, and metastasis.

Purpose of the Study:

  • To review the complex roles of iron in cancer biology.
  • To explore how cancer cells manipulate iron metabolism.
  • To discuss the therapeutic potential of targeting iron in cancer treatment.

Main Methods:

  • Literature review of epidemiological and experimental studies.
  • Analysis of the molecular mechanisms underlying iron dysregulation in cancer.
  • Examination of iron-dependent cell death pathways, such as ferroptosis.

Main Results:

  • Cancer cells exhibit an "iron-seeking" phenotype due to dysregulated iron metabolism, often influenced by oncogenes and tumor suppressors.
  • Iron is implicated in key cancer processes including proliferation, metabolism, and metastasis.
  • Both iron excess and iron deficiency can be exploited for anticancer therapies.

Conclusions:

  • Iron metabolism is a critical factor in cancer progression and presents a viable therapeutic target.
  • Targeting iron pathways, including ferroptosis, offers novel strategies for cancer treatment.
  • Further research into iron-targeted therapies holds significant promise for clinical impact.